ADCY5 ELISA Kit (Human) (OKCD00835)
Description of target: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca2+ in response to increased blood glucose levels and contributes to the regulation of Ca2+-dependent insulin secretion (PubMed:24740569).4 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.5"Raf kinase activation of adenylyl cyclases: isoform-selective regulation."_x005F_x005F_x000D_Ding Q., Gros R., Gray I.D., Taussig R., Ferguson S.S., Feldman R.D._x005F_x005F_x000D_Mol. Pharmacol. 66:921-928(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, COFACTOR, SUBCELLULAR LOCATION, PHOSPHORYLATION BY RAF1, INTERACTION WITH RAF1, ENZYME REGULATION.Ref.6"ADCY5 couples glucose to insulin secretion in human islets."_x005F_x005F_x000D_Hodson D.J., Mitchell R.K., Marselli L., Pullen T.J., Gimeno Brias S., Semplici F., Everett K.L., Cooper D.M., Bugliani M., Marchetti P., Lavallard V., Bosco D., Piemonti L., Johnson P.R., Hughes S.J., Li D., Li W.H., Shapiro A.M., Rutter G.A._x005F_x005F_x000D_Diabetes 63:3009-3021(2014) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY.Ref.7"Adenylyl cyclase 5 regulation by Gbetagamma involves isoform specific use of multiple interaction sites."_x005F_x005F_x000D_Brand C.S., Sadana R., Malik S., Smrcka A.V., Dessauer C.W._x005F_x005F_x000D_Mol. Pharmacol. 88:758-767(2015) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH GNAS; GNB1 AND GNG2, FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION.Ref.9"Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia."_x005F_x005F_x000D_Chen Y.Z., Friedman J.R., Chen D.H., Chan G.C., Bloss C.S., Hisama F.M., Topol S.E., Carson A.R., Pham P.H., Bonkowski E.S., Scott E.R., Lee J.K., Zhang G., Oliveira G., Xu J., Scott-Van Zeeland A.A., Chen Q., Levy S. , Topol E.J., Storm D., Swanson P.D., Bird T.D., Schork N.J., Raskind W.H., Torkamani A._x005F_x005F_x000D_Ann. Neurol. 75:542-549(2014) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANT FDFM TRP-418, CHARACTERIZATION OF VARIANTS FDFM TRP-418 AND THR-726, FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.124 ng/mL
Număr Catalog 247-OKCD00835CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle 
