Description of target: Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca2+ uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity).By similarity
 <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toiUniProtKB:Q01341 (ADCY6_MOUSE)UniProtKB:Q03343 (ADCY6_RAT)2 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.11"Increased enzyme activity and beta-adrenergic mediated vasodilation in subjects expressing a single-nucleotide variant of human adenylyl cyclase 6."_x005F_x005F_x000D_Gros R., Van Uum S., Hutchinson-Jaffe A., Ding Q., Pickering J.G., Hegele R.A., Feldman R.D._x005F_x005F_x000D_Arterioscler. Thromb. Vasc. Biol. 27:2657-2663(2007) [PubMed] [Europe PMC] [Abstract]Cited for: VARIANT SER-674, CHARACTERIZATION OF VARIANT SER-674, CATALYTIC ACTIVITY, ENZYME REGULATION, FUNCTION, TISSUE SPECIFICITY.Ref.12"Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits."_x005F_x005F_x000D_Gao X., Sadana R., Dessauer C.W., Patel T.B._x005F_x005F_x000D_J. Biol. Chem. 282:294-302(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION, INTERACTION WITH GNAS; GNB1 AND GNG2. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.128 ng/mL
4257.79RON
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Număr Catalog 247-OKCD00836CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
