Description of target: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.8 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.12"Identification of stathmin as a novel substrate for p38 delta."_x005F_x005F_x000D_Parker C.G., Hunt J., Diener K., McGinley M., Soriano B., Keesler G.A., Bray J., Yao Z., Wang X.S., Kohno T., Lichenstein H.S._x005F_x005F_x000D_Biochem. Biophys. Res. Commun. 249:791-796(1998) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN PHOSPHORYLATION OF STMN1.Ref.15"A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta."_x005F_x005F_x000D_Knebel A., Morrice N., Cohen P._x005F_x005F_x000D_EMBO J. 20:4360-4369(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, ENZYME REGULATION.Ref.16"Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells."_x005F_x005F_x000D_Buee-Scherrer V., Goedert M._x005F_x005F_x000D_FEBS Lett. 515:151-154(2002) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN PHOSPHORYLATION OF MAPT.Ref.17"Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly."_x005F_x005F_x000D_Feijoo C., Campbell D.G., Jakes R., Goedert M., Cuenda A._x005F_x005F_x000D_J. Cell Sci. 118:397-408(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN PHOSPHORYLATION OF MAPT.Ref.18"Activation of PKCdelta and p38delta MAPK during okadaic acid dependent keratinocyte apoptosis."_x005F_x005F_x000D_Kraft C.A., Efimova T., Eckert R.L._x005F_x005F_x000D_Arch. Dermatol. Res. 299:71-83(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN KERATINOCYTE APOPTOSIS.Ref.19"p38MAPK delta controls c-Myb degradation in response to stress."_x005F_x005F_x000D_Pani E., Ferrari S._x005F_x005F_x000D_Blood Cells Mol. Dis. 40:388-394(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN PHOSPHORYLATION OF MYB.Ref.21"MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta."_x005F_x005F_x000D_Zhou X., Ferraris J.D., Dmitrieva N.I., Liu Y., Burg M.B._x005F_x005F_x000D_Proc. Natl. Acad. Sci. U.S.A. 105:5620-5625(2008) [PubMed] [Europe PMC] [Abstract]Cited for: DEPHOSPHORYLATION BY DUSP1, FUNCTION.Ref.23"Human p38 delta MAP kinase mediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL14."_x005F_x005F_x000D_Ozawa S., Ito S., Kato Y., Kubota E., Hata R._x005F_x005F_x000D_Biochem. Biophys. Res. Commun. 396:1060-1064(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.061 ng/mL
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Număr Catalog 247-OKCD00395CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
