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MAPK12 ELISA Kit (Human) (OKCD00394)
Description of target: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.7 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation."_x005F_x005F_x000D_Lechner C., Zahalka M.A., Giot J.-F., Moeller N.P.H., Ullrich A._x005F_x005F_x000D_Proc. Natl. Acad. Sci. U.S.A. 93:4355-4359(1996) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF TYR-185.Ref.7"Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6."_x005F_x005F_x000D_Enslen H., Raingeaud J., Davis R.J._x005F_x005F_x000D_J. Biol. Chem. 273:1741-1748(1998) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN PHOSPHORYLATION OF ATF2; ELK1 AND MBP, ENZYME REGULATION.Ref.10"Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest."_x005F_x005F_x000D_Wang X., McGowan C.H., Zhao M., He L., Downey J.S., Fearns C., Wang Y., Huang S., Han J._x005F_x005F_x000D_Mol. Cell. Biol. 20:4543-4552(2000) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN REGULATION OF THE G2 CHECKPOINT.Ref.13"p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle."_x005F_x005F_x000D_Ho R.C., Alcazar O., Fujii N., Hirshman M.F., Goodyear L.J._x005F_x005F_x000D_Am. J. Physiol. 286:R342-R349(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.15"p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response."_x005F_x005F_x000D_Qi X., Pohl N.M., Loesch M., Hou S., Li R., Qin J.Z., Cuenda A., Chen G._x005F_x005F_x000D_J. Biol. Chem. 282:31398-31408(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION, UBIQUITINATION.Ref.16"p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock."_x005F_x005F_x000D_Sabio G., Cerezo-Guisado M.I., Del Reino P., Inesta-Vaquera F.A., Rousseau S., Arthur J.S., Campbell D.G., Centeno F., Cuenda A._x005F_x005F_x000D_J. Cell Sci. 123:2596-2604(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN PHOSPHORYLATION OF DLG1.Ref.18"Loss of p38gamma MAPK induces pleiotropic mitotic defects and massive cell death."_x005F_x005F_x000D_Kukkonen-Macchi A., Sicora O., Kaczynska K., Oetken-Lindholm C., Pouwels J., Laine L., Kallio M.J._x005F_x005F_x000D_J. Cell Sci. 124:216-227(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.072 ng/mL
997.2 EUR
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Număr Catalog 247-OKCD00394CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
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