IL1RAP ELISA Kit (Mouse) (OKCD00778)
Description of target: Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Coreceptor for IL1RL1 in the IL-33 signaling system.1 Publication
 <p>Manually curated information that is based on statements in scientific articles for which there is no experimental support.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000303">More…</a></p> Manual assertion based on opinion iniRef.16"Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity."_x005F_x005F_x000D_Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M., Gabel C.A., Sims J.E._x005F_x005F_x000D_J. Biol. Chem. 286:42594-42602(2011) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH IL1RL2, SUBUNIT.By similarity
 <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toiUniProtKB:Q9NPH3 (IL1AP_HUMAN)5 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.7"Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling."_x005F_x005F_x000D_Radons J., Gabler S., Wesche H., Korherr C., Hofmeister R., Falk W._x005F_x005F_x000D_J. Biol. Chem. 277:16456-16463(2002) [PubMed] [Europe PMC] [Abstract]Cited for: MUTAGENESIS OF 527-LYS--PRO-534, INTERACTION WITH MYD88, FUNCTION.Ref.9"Soluble interleukin-1 receptor accessory protein ameliorates collagen-induced arthritis by a different mode of action from that of interleukin-1 receptor antagonist."_x005F_x005F_x000D_Smeets R.L., Joosten L.A., Arntz O.J., Bennink M.B., Takahashi N., Carlsen H., Martin M.U., van den Berg W.B., van de Loo F.A._x005F_x005F_x000D_Arthritis Rheum. 52:2202-2211(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.10"IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex."_x005F_x005F_x000D_Chackerian A.A., Oldham E.R., Murphy E.E., Schmitz J., Pflanz S., Kastelein R.A._x005F_x005F_x000D_J. Immunol. 179:2551-2555(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT.Ref.11"IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells."_x005F_x005F_x000D_Ali S., Huber M., Kollewe C., Bischoff S.C., Falk W., Martin M.U._x005F_x005F_x000D_Proc. Natl. Acad. Sci. U.S.A. 104:18660-18665(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH IL1RL1.Ref.12"The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33."_x005F_x005F_x000D_Palmer G., Lipsky B.P., Smithgall M.D., Meininger D., Siu S., Talabot-Ayer D., Gabay C., Smith D.E._x005F_x005F_x000D_Cytokine 42:358-364(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH IL1RL1. Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling.2 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.9"Soluble interleukin-1 receptor accessory protein ameliorates collagen-induced arthritis by a different mode of action from that of interleukin-1 receptor antagonist."_x005F_x005F_x000D_Smeets R.L., Joosten L.A., Arntz O.J., Bennink M.B., Takahashi N., Carlsen H., Martin M.U., van den Berg W.B., van de Loo F.A._x005F_x005F_x000D_Arthritis Rheum. 52:2202-2211(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.12"The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33."_x005F_x005F_x000D_Palmer G., Lipsky B.P., Smithgall M.D., Meininger D., Siu S., Talabot-Ayer D., Gabay C., Smith D.E._x005F_x005F_x000D_Cytokine 42:358-364(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH IL1RL1. Isoform 3: Required for Src phosphorylation by IL1B. Required for IL1B-potentiated NMDA-induced calcium influx in neurons acting in cooperation with IL1R1 isoform 2 to mediate Akt kinase activation.2 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.17"Neuron-specific effects of interleukin-1beta are mediated by a novel isoform of the IL-1 receptor accessory protein."_x005F_x005F_x000D_Huang Y., Smith D.E., Ibanez-Sandoval O., Sims J.E., Friedman W.J._x005F_x005F_x000D_J. Neurosci. 31:18048-18059(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION (ISOFORM 3), TISSUE SPECIFICITY (ISOFORM 3).Ref.18"Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase."_x005F_x005F_x000D_Qian J., Zhu L., Li Q., Belevych N., Chen Q., Zhao F., Herness S., Quan N._x005F_x005F_x000D_Proc. Natl. Acad. Sci. U.S.A. 109:12189-12194(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION (ISOFORM 3). ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 13.4 pg/mL
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Număr Catalog 247-OKCD00778CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
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