IL1RAP ELISA Kit (Human) (OKCD00549)
Description of target: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system.By similarity
 <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toiUniProtKB:Q61730 (IL1AP_MOUSE)1 Publication
 <p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000305">More…</a></p> Manual assertion inferred by curator fromiRef.17"Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes."_x005F_x005F_x000D_Lingel A., Weiss T.M., Niebuhr M., Pan B., Appleton B.A., Wiesmann C., Bazan J.F., Fairbrother W.J._x005F_x005F_x000D_Structure 17:1398-1410(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, MODEL OF THE IL-33 SIGNALING COMPLEX.2 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein."_x005F_x005F_x000D_Huang J., Gao X., Li S., Cao Z._x005F_x005F_x000D_Proc. Natl. Acad. Sci. U.S.A. 94:12829-12832(1997) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH IL1R1 AND IRAK1.Ref.3"IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein."_x005F_x005F_x000D_Jensen L.E., Muzio M., Mantovani A., Whitehead A.S._x005F_x005F_x000D_J. Immunol. 164:5277-5286(2000) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), FUNCTION, INDUCTION BY PHORBOL ESTERS. Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).By similarity
 <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toiUniProtKB:Q61730 (IL1AP_MOUSE)1 Publication
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.13"The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action."_x005F_x005F_x000D_Smith D.E., Hanna R., Friend D., Moore H., Chen H., Farese A.M., MacVittie T.J., Virca G.D., Sims J.E._x005F_x005F_x000D_Immunity 18:87-96(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION (SECRETED FORMS), TISSUE SPECIFICITY. Isoform 4: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity).By similarity
 <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toiUniProtKB:Q61730 (IL1AP_MOUSE)1 Publication
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.6"A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1."_x005F_x005F_x000D_Smith D.E., Lipsky B.P., Russell C., Ketchem R.R., Kirchner J., Hensley K., Huang Y., Friedman W.J., Boissonneault V., Plante M.M., Rivest S., Sims J.E._x005F_x005F_x000D_Immunity 30:817-831(2009) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION (ISOFORM 4), TISSUE SPECIFICITY (ISOFORM 4), INTERACTION WITH IL1R1. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.065 ng/mL
997.2 EUR
Preț : 997.2 €
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Număr Catalog 247-OKCD00549CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
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