MX1 ELISA Kit (Human) (OKCD00718)
Description of target: Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.13 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.17"Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes."_x005F_x005F_x000D_Kochs G., Janzen C., Hohenberg H., Haller O._x005F_x005F_x000D_Proc. Natl. Acad. Sci. U.S.A. 99:3153-3158(2002) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH LACV PROTEIN N, MUTAGENESIS OF GLU-645.Ref.18"Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus."_x005F_x005F_x000D_Andersson I., Bladh L., Mousavi-Jazi M., Magnusson K.E., Lundkvist A., Haller O., Mirazimi A._x005F_x005F_x000D_J. Virol. 78:4323-4329(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CCHFV PROTEIN N, MUTAGENESIS OF GLU-645.Ref.19"Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome."_x005F_x005F_x000D_Turan K., Mibayashi M., Sugiyama K., Saito S., Numajiri A., Nagata K._x005F_x005F_x000D_Nucleic Acids Res. 32:643-652(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.20"Missorting of LaCrosse virus nucleocapsid protein by the interferon-induced MxA GTPase involves smooth ER membranes."_x005F_x005F_x000D_Reichelt M., Stertz S., Krijnse-Locker J., Haller O., Kochs G._x005F_x005F_x000D_Traffic 5:772-784(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION.Ref.21"Inhibition of Dugbe nairovirus replication by human MxA protein."_x005F_x005F_x000D_Bridgen A., Dalrymple D.A., Weber F., Elliott R.M._x005F_x005F_x000D_Virus Res. 99:47-50(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.22"MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."_x005F_x005F_x000D_Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G._x005F_x005F_x000D_J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH TRPC1; TRPC3; TRPC4; TRPC5; TRPC6 AND TRPC7, MUTAGENESIS OF LYS-83; THR-103 AND LEU-612.Ref.23"Assay and functional analysis of dynamin-like Mx proteins."_x005F_x005F_x000D_Kochs G., Reichelt M., Danino D., Hinshaw J.E., Haller O._x005F_x005F_x000D_Methods Enzymol. 404:632-643(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, OLIGOMERIZATION, INTERACTION WITH LACV PROTEIN N.Ref.26"Expression of the interferon-alpha/beta-inducible bovine Mx1 dynamin interferes with replication of rabies virus."_x005F_x005F_x000D_Leroy M., Pire G., Baise E., Desmecht D._x005F_x005F_x000D_Neurobiol. Dis. 21:515-521(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.27"Human MxA protein confers resistance to double-stranded RNA viruses of two virus families."_x005F_x005F_x000D_Mundt E._x005F_x005F_x000D_J. Gen. Virol. 88:1319-1323(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.29"GTPase activity is not essential for the interferon-inducible MxA protein to inhibit the replication of hepatitis B virus."_x005F_x005F_x000D_Yu Z., Wang Z., Chen J., Li H., Lin Z., Zhang F., Zhou Y., Hou J._x005F_x005F_x000D_Arch. Virol. 153:1677-1684(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.30"Inhibition of a large double-stranded DNA virus by MxA protein."_x005F_x005F_x000D_Netherton C.L., Simpson J., Haller O., Wileman T.E., Takamatsu H.H., Monaghan P., Taylor G._x005F_x005F_x000D_J. Virol. 83:2310-2320(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION.Ref.34"Stalk domain of the dynamin-like MxA GTPase protein mediates membrane binding and liposome tubulation via the unstructured L4 loop."_x005F_x005F_x000D_von der Malsburg A., Abutbul-Ionita I., Haller O., Kochs G., Danino D._x005F_x005F_x000D_J. Biol. Chem. 286:37858-37865(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-554; LYS-555; LYS-556 AND LYS-557.Ref.36"Interferon-inducible antiviral protein MxA enhances cell death triggered by endoplasmic reticulum stress."_x005F_x005F_x000D_Numajiri Haruki A., Naito T., Nishie T., Saito S., Nagata K._x005F_x005F_x000D_J. Interferon Cytokine Res. 31:847-856(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH HSPA5. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.64 ng/mL
1090.8 EUR
Preț : 1090.8 €
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Număr Catalog 247-OKCD00718CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
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