Description of target: Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.4 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.7"Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB."_x005F_x005F_x000D_King M.C., Raposo G., Lemmon M.A._x005F_x005F_x000D_Proc. Natl. Acad. Sci. U.S.A. 101:8957-8962(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-131 AND THR-151.Ref.11"The interferon-inducible MxB protein inhibits HIV-1 infection."_x005F_x005F_x000D_Liu Z., Pan Q., Ding S., Qian J., Xu F., Zhou J., Cen S., Guo F., Liang C._x005F_x005F_x000D_Cell Host Microbe 14:398-410(2013) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN HIV-1 RESTRICTION.Ref.12"Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection."_x005F_x005F_x000D_Goujon C., Moncorge O., Bauby H., Doyle T., Ward C.C., Schaller T., Hue S., Barclay W.S., Schulz R., Malim M.H._x005F_x005F_x000D_Nature 502:559-562(2013) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN HIV-1 RESTRICTION.Ref.13"MX2 is an interferon-induced inhibitor of HIV-1 infection."_x005F_x005F_x000D_Kane M., Yadav S.S., Bitzegeio J., Kutluay S.B., Zang T., Wilson S.J., Schoggins J.W., Rice C.M., Yamashita M., Hatziioannou T., Bieniasz P.D._x005F_x005F_x000D_Nature 502:563-566(2013) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN HIV-1 RESTRICTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.055 ng/mL
4886.78RON
În stoc
Număr Catalog 247-OKCD00610CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
