NDR or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase family that is regulated by Mob proteins . Fas and TNFa receptor stimulation activates human NDR by promoting phosphorylation at the hydrophobic motif. NDR acts as a novel pro-apoptotic kinase, and is a key member of the RASSF1A/MST1 signaling cascade . NDR is crucial for the fidelity of mitotic chromosome alignment in mammalian cells. NDR is incorporated into the HIV-1 particles and is cleaved by the HIV-1 protease. NDR-driven centrosome duplication requires Cdk2 activity, and Cdk2-induced centrosome amplification is affected upon reduction of NDR activity.
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Număr Catalog 10021-Z500246CategorieAfaceri și industrie > Știință și laboratorFurnizorABMGentaurDimensiune10 µgTipsingle