PDGFRalpha is a protein encoded by the PDGFRA gene which is approximately 122,6 kDa. PDGFRalpha is localised to the cell membrane. It is involved in RET signalling, apoptotic pathways in synovial fibroblasts and the GPCR pathway. It is a tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. It either promotes or inhibits cell proliferation and cell migration and plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. PDGFRalpha is widely expressed in the body including platelets, brain and colon. Mutations in the PDGFRA gene may result in gastrointestinal stromal tumor. STJ97793 was developed from clone 7A3 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of PDGFRalpha.
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Număr Catalog 665-STJ97793CategorieAfaceri și industrie > Știință și laboratorFurnizorSt John's LaboratoryGentaurDimensiune200 µlTipsingle
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