CD68 is a protein encoded by the CD68 gene which is approximately 37,4 kDa. CD68 short isoform is localised to the cell membrane and the long isoform is localised to the endosome membrane. It is involved in the innate immune system, stem cell differentiation pathways and lineage-specific markers. This protein falls under the lysosomal/endosomal-associated membrane glycoprotein family. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. It is also a member of the scavenger receptor family which typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. CD68 is highly expressed by blood monocytes and tissue macrophages. Mutations in the CD68 gene may result in a granular cell tumour. STJ96952 was developed from clone 6F3 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous CD68 proteins.
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Număr Catalog 665-STJ96952CategorieAfaceri și industrie > Știință și laboratorFurnizorSt John's LaboratoryGentaurDimensiune200 µlTipsingle
