SUMO-1 is a protein encoded by the SUMO1 gene which is approximately 11,6 kDa. SUMO-1 is localised to the nuclear membrane and nucelus. It is involved in SUMOylation, DNA double-strand break repair, transcription-coupled nucleotide excision repair and interferon gamma signalling. This protein falls under the SUMO protein family. It functions similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. This protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO-1 is expressed in the cells of the nervous system, liver, lung, kidney and blood. Mutations in the SUMO1 gene result in disease such as non-syndromic orofacial cleft 10 which is a birth defect exhibiting cleft lips which can range in severity and can occur on one or both sides. TJ95835 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody binds endogenous SUMO-1.
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Număr Catalog 665-STJ95835CategorieAfaceri și industrie > Știință și laboratorFurnizorSt John's LaboratoryGentaurDimensiune200 µlTipsingle
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