Cox-2 is a protein encoded by the PTGS2 gene which is approximately 68,9 kDa. Cox-2 is localised to the endoplasmic reticulum membrane. It is involved in PEDF induced signalling, arachidonic acid metabolism, aspirin triggered resolvin E biosynthesis and cytokine signalling. It is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. Cox-2 is expressed in cytokines and mitogens. Mutations in the PTGS2 gene may result in colorectal adenoma and chronic pain. STJ92438 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Cox-2 protein.
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Număr Catalog 665-STJ92438CategorieAfaceri și industrie > Știință și laboratorFurnizorSt John's LaboratoryGentaurDimensiune200 µlTipsingle
