YAP is a protein encoded by the YAP1 gene which is approximately 54,5 kDa. YAP is localised to the cytoplasm and nucleus. It is involved in signalling by ERBB4, gene expression, metabolism and hippo signalling pathway. It is a transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signalling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. YAP is expressed in the liver, lung, nervous system, pancreas and skin with increased expression seen in some liver and prostate cancers. Mutations in the YAP1 gene may result in Coloboma.This primary antibody specifically binds to endogenous YAP protein which only binds about S127 when S127 is phosphorylated.
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Număr Catalog 665-STJ90868CategorieAfaceri și industrie > Știință și laboratorFurnizorSt John's LaboratoryGentaurDimensiune200 µlTipsingle
