EGFR is a protein encoded by the EGFR gene which is approximately 134,3 kDa. EGFR is localised to the cell membrane. and endoplasmic reticulum membrane. It is involved in RET signalling, apoptotic pathways in synovial fibroblasts, glioma and the GPCR pathway. It is a transmembrane glycoprotein that is a member of the protein kinase superfamily. It binds to epidermal growth factor and this induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. EGFR is expressed ubiquitously with isoform 2 also being expressed in ovarian cancers. Mutations in the EGFR gene may result in lung cancer and Cowden syndrome. STJ90568 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous EGFR protein which only binds about S1071 when S1071 is phosphorylated.
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În stoc
Număr Catalog 665-STJ90568CategorieAfaceri și industrie > Știință și laboratorFurnizorSt John's LaboratoryGentaurDimensiune200 µlTipsingle
