NFkappaB-p65 is a protein encoded by the RELA gene which is approximately 60,2 kDa. NFkappaB-p65 is localised to the nucleus and cytoplasm. It is involved in activated TLR4 signalling, toll-like receptor signalling pathways, cytosolic sensors of pathogen-associated DNA and immune response. NF-kappa-B is a transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NFkappaB-p65 is expressed in the nervous system, intestine, bone, lung and skin. Mutations in the RELA gene result in Ependymoma, Reticuloendotheliosis and Retinitis Pigmentosa-50. STJ90347 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous NFkappaB-p65 protein which only binds about S276 when S276 is phosphorylated.
1059.07RON
În stoc
Număr Catalog 665-STJ90347CategorieAfaceri și industrie > Știință și laboratorFurnizorSt John's LaboratoryGentaurDimensiune200 µlTipsingle
