Caspase-7 is a protein encoded by the CASP7 gene which is approximately 34,2 kDa. Caspase-7 is localised to the cytoplasm. It is involved in the TNFR1 pathway and apoptosis modulation and signalling. It exists as an inactive proenzyme which undergoes proteolytic processing at conserved aspartic residues to produce two subunits that dimerize to form the active enzyme. It is involved in the activation cascade of caspases responsible for apoptosis execution. Caspase-7 is highly expressed in the lung, skeletal muscle, liver, kidney, spleen and heart. Mutations in the CASP7 gene may result in breast adenocarcinoma. STJ90031 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Caspase-7 protein.
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În stoc
Număr Catalog 665-STJ90031CategorieAfaceri și industrie > Știință și laboratorFurnizorSt John's LaboratoryGentaurDimensiune200 µlTipsingle
