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Qβ VLP
Download Whitepaper:Qß1-VLP Based Anti-Fungal Peptide Vaccines Induce Robust Immunity Rashidijahanabad, Z.; Kelly, M.; Kamruzzaman, M.; Qadri, F.; Bhuiyan, T. R.; McFall-Boegeman, H.; Wu, D.; Piszczek, G.; Xu, P.; * Ryan, E. T.; * Huang, X.*“Virus like particle display of Vibrio cholerae O-specific polysaccharide as a potential vaccine against cholera”ACS Infect. Dis. 2022,8 (3), 574–583. Sungsuwan, S.; Wu, X.; Kavunja, H.; McFall-Boegeman, H.; Lang, S.; Rashidijahanabad, Z.; Nick, S. T.; Shaw, V.; Yin, Z.; Jin, X.*; Huang, X.* “Structure Guided Design of Bacteriophage Qβ Mutants as Next Generation Carriers for Conjugate Vaccines”ACS Chem. Biol.,2022, in press. Wu, X.; Ye, J.; Kavunja, H.; DeLaitsch, A.; Rashidijahanabad, Z.; Lang, S.; Kakeshpour, T.; Zhao, Y.; Ramadan, S.; Vilar Saavedra, P.; Yuzbasiyan-Gurkan, V.; Cao, H.*; Gildersleeve, J. C.*; Huang, X.*“Chemoenzymatic Synthesis of 9NHAc-GD2 Antigen to Overcome Hydrolytic Instability ofO-Acetylated-GD2 for Anticancer Conjugate Vaccine Development”Angew. Chem. Int. Ed.2021,60,24179-24188. Wu, X.; McFall-Boegeman H.; Rashidijahanabad, Z.; Liu, K.; Pett, C.; Yu, J.; Schorlemer, M.; Ramadan, S.; Behren, S.; Westerlind, U.; Huang, X.*“Synthesis and Immunological Evaluation of the Unnatural β-linked Mucin-1 Thomsen-Friedenreich Conjugate”Org. Biomol. Chem.2021,19,2448-2455. Wang, P.; Huo, C.-X.; Lang, S.; Caution, K.; Nick, S. T.; Dubey, P.; Deora, R.; * Huang, X.* “ Chemical Synthesis and Immunological Evaluation of a Pentasaccharide Bearing Multiple Rare Sugars as a Potential Antipertussis Vaccine.”Angew. Chem. Int. Ed.2020,59,6451–6458. Highlighted inSynfacts2020,16,0471.https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0040-1707573.pdf Dhara, D., Baliban, S. M.; Huo, C.-X.; Rashidijahanabad, Z.; Sears, K. T.; Nick, S. T.; Misra, A. K.; * Tennant, S. M.; *Huang, X.* “Syntheses of Salmonella Paratyphi A Associated Oligosaccharide Antigens and Development towards Anti-Paratyphoid Fever Vaccines.”Chem. Eur. J.2020,26,15953-15968. Wu. X.; McKay, C.; Pett, C.; Yu, J.; Schorlemer, M.; Ramadan, S.; Lang, S.; Westerlind, U.; Finn, M. G.; Huang, X.* “Synthesis and Immunological Evaluation of Disaccharide Bearing MUC-1 Glycopeptide Conjugates with Virus-like Particles.”ACS. Chem. Biol.2019,14,2176-2184. This work has been highlighted as the cover of the issue.https://pubs.acs.org/pb-assets/images/_journalCovers/acbcct/acbcct_v014i010.jpg?0.6312907862471471 Huo, C.-X.; Dhara, D., Baliban, S. M.; Nick, S. T.; Tan, Z.; Simon, R.; Misra, A. K.; Huang, X.* “Synthetic and immunological studies of Salmonella Enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines.”Chem. Commun.2019,55,4519-4522. Wu. X.; Yin, Z.; McKay, C.; Pett, C.; Yu, J.; Schorlemer, M.; Gohl, T.; Sungsuwan, S.; Ramadan, S.; Baniel, C.; Allmon, A.; Das, R.; Westerlind, U.; Finn, M. G.; Huang, X.* “Protective Epitope Discovery and Design of MUC1-based Vaccine for Effective Tumor Protections in Immunotolerant Mice.”J. Am. Chem. Soc.2018,140,16596-16609. Yin, Z.; Wu. X.; Kaczanowska, K.; Sungsuwan, S.; Comellas-Aragones, M.; Pett C., Yu J.; Baniel, C.; Westerlind, U.; Finn, M. G.; Huang, X.* “Antitumor Humoral and T Cell Responses by Mucin-1 Conjugates of Bacteriophage Qβ in Wild-type Mice.”ACS Chem. Biol.2018,13,1668-1676. Yin, Z.; Dulaney, S.: McKay, C. S.; Baniel, C.; Kaczanowska, K.; Ramadan, S.; Finn, M. G.; Huang, X.* “Chemical Synthesis of GM2 Glycans, Bioconjugation with Bacteriophage Qb, and the Induction of Anticancer Antibodies.”ChemBiochem2016,17,174-180. Yin, Z.; Chowdhury, S.; McKay, C.; Baniel, C.; Wright, W. S.; Bentley, P.; Kaczanowska, K.; Gildersleeve, J. C.; Finn, M. G.; BenMohamed, L.; Huang, X.* “Significant Impact of Immunogen Design on the Diversity of Antibodies Generated by Carbohydrate-Based Anticancer Vaccine.”ACS Chem. Biol.2015,10,2364-2372. This work has also been highlighted in the October 2015 POD cast fromACS Chemical Biology.http://pubs.acs.org/page/acbcct/audio/index.html Yin, Z.; Comellas-Aragones, M.; Chowdhury, S.; Bentley, P.; Kaczanowska, K.; BenMohamed, L.; Gildersleeve, J. C.; Finn, M.G.*; Huang, X.* “Boosting Immunity to Small Tumor-Associated Carbohydrates with Bacteriophage Qβ Capsids.”ACS Chem. Biol.2013,8, 1253-1262.This work has been highlighted byChemical & Engineering News, http://cen.acs.org/articles/91/web/2013/04/Sugar-Coated-Particles-Provoke-Immune.htmlas well as in the June 2013 POD cast fromACS Chemical Biology.http://pubs.acs.org/page/acbcct/audio/index.html
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