CCND2 ELISA Kit (Mouse) (OKEH05795) Aviva Systems Biology

CCND2 ELISA Kit (Mouse) (OKEH05795)

Description of target: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.164 ng/mL

Preț : 794.4 €

În stoc

Număr Catalog 247-OKEH05795

CategorieAfaceri și industrie > Știință și laboratorFurnizorGentaurDimensiune96 WellsTipsingle

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CCND2 ELISA Kit (Mouse) (OKEH05795)

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