Description of target: Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.3 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"LEKTI, a novel 15-domain type of human serine proteinase inhibitor."_x005F_x005F_x000D__x000D_Maegert H.-J., Staendker L., Kreutzmann P., Zucht H.-D., Reinecke M., Sommerhoff C.P., Fritz H., Forssmann W.-G._x005F_x005F_x000D__x000D_J. Biol. Chem. 274:21499-21502(1999) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS F-L), PARTIAL PROTEIN SEQUENCE, VARIANTS ARG-267; VAL-335; ASN-368; GLU-420 AND GLN-711, FUNCTION, TISSUE SPECIFICITY.Ref.7"LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction."_x005F_x005F_x000D__x000D_Deraison C., Bonnart C., Lopez F., Besson C., Robinson R., Jayakumar A., Wagberg F., Brattsand M., Hachem J.P., Leonardsson G., Hovnanian A._x005F_x005F_x000D__x000D_Mol. Biol. Cell 18:3607-3619(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CLEAVAGE BY FURIN, INHIBITION OF KLK5; KLK7 AND KLK14.Ref.8"New role for LEKTI in skin barrier formation: label-free quantitative proteomic identification of caspase 14 as a novel target for the protease inhibitor LEKTI."_x005F_x005F_x000D__x000D_Bennett K., Callard R., Heywood W., Harper J., Jayakumar A., Clayman G.L., Di W.L., Mills K._x005F_x005F_x000D__x000D_J. Proteome Res. 9:4289-4294(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INHIBITION OF CASP14. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.113 ng/mL
4467.46RON
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Număr Catalog 247-OKCD01025CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
