Description of target: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.4 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"Inhibition of Hsp70 ATPase activity and protein renaturation by a novel Hsp70-binding protein."_x005F_x005F_x000D_Raynes D.A., Guerriero V. Jr._x005F_x005F_x000D_J. Biol. Chem. 273:32883-32888(1998) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT 25-GLY--GLY-27 DEL, FUNCTION, INTERACTION WITH HSPA1A, TISSUE SPECIFICITY.Ref.2"Isolation and characterization of isoforms of HspBP1, inhibitors of Hsp70."_x005F_x005F_x000D_Guerriero V. Jr., Raynes D.A._x005F_x005F_x000D_Biochim. Biophys. Acta 1490:203-207(2000) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, POLYMORPHISM OF POLY-GLY REGION.Ref.9"HspBP1, an Hsp70 cochaperone, has two structural domains and is capable of altering the conformation of the Hsp70 ATPase domain."_x005F_x005F_x000D_McLellan C.A., Raynes D.A., Guerriero V. Jr._x005F_x005F_x000D_J. Biol. Chem. 278:19017-19022(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH HSPA1A.Ref.10"The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator."_x005F_x005F_x000D_Alberti S., Boehse K., Arndt V., Schmitz A., Hoehfeld J._x005F_x005F_x000D_Mol. Biol. Cell 15:4003-4010(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH HSPA1A AND STUB1. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.118 ng/mL
997.2EUR
În stoc
Număr Catalog 247-OKCD00909CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
