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DROSHA ELISA Kit (Human) (OKCD00897)
Description of target: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.11 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"Human RNase III is a 160-kDa protein involved in preribosomal RNA processing."_x005F_x005F_x000D_Wu H., Xu H., Miraglia L.J., Crooke S.T._x005F_x005F_x000D_J. Biol. Chem. 275:36957-36965(2000) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.Ref.8"The nuclear RNase III Drosha initiates microRNA processing."_x005F_x005F_x000D_Lee Y., Ahn C., Han J., Choi H., Kim J., Yim J., Lee J., Provost P., Raadmark O., Kim S., Kim V.N._x005F_x005F_x000D_Nature 425:415-419(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.9"The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis."_x005F_x005F_x000D_Landthaler M., Yalcin A., Tuschl T._x005F_x005F_x000D_Curr. Biol. 14:2162-2167(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH DGCR8.Ref.10"The Drosha-DGCR8 complex in primary microRNA processing."_x005F_x005F_x000D_Han J., Lee Y., Yeom K.-H., Kim Y.-K., Jin H., Kim V.N._x005F_x005F_x000D_Genes Dev. 18:3016-3027(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, IDENTIFICATION IN THE MICROPROCESSOR COMPLEX, INTERACTION WITH DGCR8, CATALYTIC ACTIVITY, COFACTOR, DOMAIN, MUTAGENESIS OF GLU-993; GLU-1045; GLU-1171 AND GLU-1222.Ref.11"The microprocessor complex mediates the genesis of microRNAs."_x005F_x005F_x000D_Gregory R.I., Yan K.-P., Amuthan G., Chendrimada T., Doratotaj B., Cooch N., Shiekhattar R._x005F_x005F_x000D_Nature 432:235-240(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, IDENTIFICATION IN THE MICROPROCESSOR COMPLEX.Ref.12"Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha."_x005F_x005F_x000D_Zeng Y., Yi R., Cullen B.R._x005F_x005F_x000D_EMBO J. 24:138-148(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY.Ref.13"Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex."_x005F_x005F_x000D_Han J., Lee Y., Yeom K.-H., Nam J.-W., Heo I., Rhee J.-K., Sohn S.Y., Cho Y., Zhang B.-T., Kim V.N._x005F_x005F_x000D_Cell 125:887-901(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, IDENTIFICATION IN THE MICROPROCESSOR COMPLEX.Ref.14"Formation of GW bodies is a consequence of microRNA genesis."_x005F_x005F_x000D_Pauley K.M., Eystathioy T., Jakymiw A., Hamel J.C., Fritzler M.J., Chan E.K.L._x005F_x005F_x000D_EMBO Rep. 7:904-910(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION.Ref.15"Heme is involved in microRNA processing."_x005F_x005F_x000D_Faller M., Matsunaga M., Yin S., Loo J.A., Guo F._x005F_x005F_x000D_Nat. Struct. Mol. Biol. 14:23-29(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.21"Functional anatomy of the human microprocessor."_x005F_x005F_x000D_Nguyen T.A., Jo M.H., Choi Y.G., Park J., Kwon S.C., Hohng S., Kim V.N., Woo J.S._x005F_x005F_x000D_Cell 161:1374-1387(2015) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT, CATALYTIC ACTIVITY, MUTAGENESIS OF GLU-1045 AND GLU-1222.Ref.23"Structure of human DROSHA."_x005F_x005F_x000D_Kwon S.C., Nguyen T.A., Choi Y.G., Jo M.H., Hohng S., Kim V.N., Woo J.S._x005F_x005F_x000D_Cell 164:81-90(2016) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 411-1365 OF MUTANT GLN-1045/GLN-1222 IN COMPLEX WITH DGCR8 AND ZINC IONS, FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH DGCR8, SUBUNIT, MUTAGENESIS OF CYS-536; CYS-538; CYS-561; 622-ARG-PHE-623; CYS-676; 835-ARG-ARG-836; ARG-914; ARG-923; TYR-927; 938-ARG--LYS-940; VAL-1077; LEU-1194 AND VAL-1243, REGION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.126 ng/mL
997.2 EUR
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Număr Catalog 247-OKCD00897CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
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