Description of target: Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.2 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.8"Glycosylation in a mammalian expression system is critical for the production of functionally active leukocyte immunoglobulin-like receptor A3 protein."_x005F_x005F_x000D_Lee T.H., Mitchell A., Liu Lau S., An H., Rajeaskariah P., Wasinger V., Raftery M., Bryant K., Tedla N._x005F_x005F_x000D_J. Biol. Chem. 288:32873-32885(2013) [PubMed] [Europe PMC] [Abstract]Cited for: GLYCOSYLATION AT ASN-140; ASN-281; ASN-302; ASN-341 AND ASN-431, FUNCTION.Ref.9"LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence."_x005F_x005F_x000D_Ryu M., Chen Y., Qi J., Liu J., Fan Z., Nam G., Shi Y., Cheng H., Gao G.F._x005F_x005F_x000D_PLoS ONE 6:E19245-E19245(2011) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 24-120, DISULFIDE BOND, FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.124 ng/mL
4257.79RON
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Număr Catalog 247-OKCD00832CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
