Description of target: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).7 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.4"A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2."_x005F_x005F_x000D_Mahajan R., Delphin C., Guan T., Gerace L., Melchior F._x005F_x005F_x000D_Cell 88:97-107(1997) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.Ref.14"Preferential modification of nuclear proteins by a novel ubiquitin-like molecule."_x005F_x005F_x000D_Kamitani T., Nguyen H.P., Yeh E.T.H._x005F_x005F_x000D_J. Biol. Chem. 272:14001-14004(1997) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, PROTEOLYTIC CLEAVAGE.Ref.27"Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25."_x005F_x005F_x000D_Meulmeester E., Kunze M., Hsiao H.H., Urlaub H., Melchior F._x005F_x005F_x000D_Mol. Cell 30:610-619(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN SUMOYLATION OF USP25, INTERACTION WITH USP25.Ref.29"RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation."_x005F_x005F_x000D_Tatham M.H., Geoffroy M.C., Shen L., Plechanovova A., Hattersley N., Jaffray E.G., Palvimo J.J., Hay R.T._x005F_x005F_x000D_Nat. Cell Biol. 10:538-546(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.31"SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability."_x005F_x005F_x000D_Dai X.Q., Kolic J., Marchi P., Sipione S., Macdonald P.E._x005F_x005F_x000D_J. Cell Sci. 122:775-779(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN KCNB1 SUMOYLATION, INTERACTION WITH KCNB1, SUBCELLULAR LOCATION.Ref.35"SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function."_x005F_x005F_x000D_Cong L., Pakala S.B., Ohshiro K., Li D.Q., Kumar R._x005F_x005F_x000D_J. Biol. Chem. 286:43793-43808(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH MTA1.Ref.44"Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells."_x005F_x005F_x000D_Sun X., Li J., Dong F.N., Dong J.T._x005F_x005F_x000D_PLoS ONE 9:E92746-E92746(2014) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.054 ng/mL
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Număr Catalog 247-OKCD00491CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
