Description of target: Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for centrosome migration to the apical cell surface during early ciliogenesis.4 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"NUANCE, a giant protein connecting the nucleus and actin cytoskeleton."_x005F_x005F_x000D_Zhen Y.-Y., Libotte T., Munck M., Noegel A.A., Korenbaum E._x005F_x005F_x000D_J. Cell Sci. 115:3207-3222(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 9), FUNCTION, CHARACTERIZATION, INTERACTION WITH F-ACTIN, VARIANTS THR-1969; VAL-2284; ASN-2359; THR-2395; GLY-2802; VAL-2942; HIS-3253; ARG-3309 AND MET-5186.Ref.15"Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness."_x005F_x005F_x000D_Stewart-Hutchinson P.J., Hale C.M., Wirtz D., Hodzic D._x005F_x005F_x000D_Exp. Cell Res. 314:1892-1905(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, DOMAIN, INTERACTION WITH SUN1 AND SUN2.Ref.17"Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton."_x005F_x005F_x000D_Dawe H.R., Adams M., Wheway G., Szymanska K., Logan C.V., Noegel A.A., Gull K., Johnson C.A._x005F_x005F_x000D_J. Cell Sci. 122:2716-2726(2009) [PubMed] [Europe PMC] [Abstract]Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MKS3, FUNCTION.Ref.22"Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement."_x005F_x005F_x000D_Luxton G.W., Gomes E.R., Folker E.S., Vintinner E., Gundersen G.G._x005F_x005F_x000D_Science 329:956-959(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.055 ng/mL
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Număr Catalog 247-OKCD00484CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
