Description of target: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.By similarity2 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis."_x005F_x005F_x000D_Kane R., Godson C., O'Brien C._x005F_x005F_x000D_Mol. Vis. 14:1138-1148(2008) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, INDUCTION.Ref.6"X-linked megalocornea caused by mutations in CHRDL1 identifies an essential role for ventroptin in anterior segment development."_x005F_x005F_x000D_Webb T.R., Matarin M., Gardner J.C., Kelberman D., Hassan H., Ang W., Michaelides M., Ruddle J.B., Pennell C.E., Yazar S., Khor C.C., Aung T., Yogarajah M., Robson A.G., Holder G.E., Cheetham M.E., Traboulsi E.I., Moore A.T. , Sowden J.C., Sisodiya S.M., Mackey D.A., Tuft S.J., Hardcastle A.J._x005F_x005F_x000D_Am. J. Hum. Genet. 90:247-259(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY, VARIANT MGC1 PHE-254. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.058 ng/mL
997.2EUR
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Număr Catalog 247-OKCD00472CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
