Description of target: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.6 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.6"Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes."_x005F_x005F_x000D_Kotenko S.V., Izotova L.S., Mirochnitchenko O.V., Esterova E., Dickensheets H., Donnelly R.P., Pestka S._x005F_x005F_x000D_J. Biol. Chem. 276:2725-2732(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT.Ref.7"STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types."_x005F_x005F_x000D_Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C._x005F_x005F_x000D_J. Immunol. 167:3545-3549(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.9"Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2."_x005F_x005F_x000D_Wang M., Tan Z., Zhang R., Kotenko S.V., Liang P._x005F_x005F_x000D_J. Biol. Chem. 277:7341-7347(2002) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.10"Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions."_x005F_x005F_x000D_Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S., Chandrasekher Y.A._x005F_x005F_x000D_J. Biol. Chem. 277:47517-47523(2002) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.11"Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor."_x005F_x005F_x000D_Ramesh R., Mhashilkar A.M., Tanaka F., Saito Y., Branch C.D., Sieger K., Mumm J.B., Stewart A.L., Boquoi A., Dumoutier L., Grimm E.A., Renauld J.-C., Kotenko S., Chada S._x005F_x005F_x000D_Cancer Res. 63:5105-5113(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.14"IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro."_x005F_x005F_x000D_Brand S., Dambacher J., Beigel F., Zitzmann K., Heeg M.H.J., Weiss T.S., Pruefer T., Olszak T., Steib C.J., Storr M., Goeke B., Diepolder H., Bilzer M., Thasler W.E., Auernhammer C.J._x005F_x005F_x000D_Am. J. Physiol. 292:G1019-G1028(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.061 ng/mL
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Număr Catalog 247-OKCD00444CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
