Description of target: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892).3 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.6"ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart."_x005F_x005F_x000D_Lamant M., Smih F., Harmancey R., Philip-Couderc P., Pathak A., Roncalli J., Galinier M., Collet X., Massabuau P., Senard J.-M., Rouet P._x005F_x005F_x000D_J. Biol. Chem. 281:36289-36302(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, COVALENT LINKAGE WITH CHONDROITIN SULFATE.Ref.8"Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart."_x005F_x005F_x000D_Turkieh A., Caubere C., Barutaut M., Desmoulin F., Harmancey R., Galinier M., Berry M., Dambrin C., Polidori C., Casteilla L., Koukoui F., Rouet P., Smih F._x005F_x005F_x000D_J. Clin. Invest. 124:2277-2286(2014) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.9"The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions."_x005F_x005F_x000D_Koob S., Barrera M., Anand R., Reichert A.S._x005F_x005F_x000D_Biochim. Biophys. Acta 1853:1551-1563(2015) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, NOMENCLATURE, IDENTIFICATION IN THE MICOS COMPLEX, SUBCELLULAR LOCATION, GLYCOSYLATION, INTERACTION WITH MINOS1; APOOL AND IMMT. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.054 ng/mL
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Număr Catalog 247-OKCD00405CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
