Description of target: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. In case of infection with vesicular stomatitis virus (VSV), impairs viral replication.5 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.6"Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha."_x005F_x005F_x000D_Novoa I., Zeng H., Harding H.P., Ron D._x005F_x005F_x000D_J. Cell Biol. 153:1011-1022(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH PP1, MUTAGENESIS OF VAL-549.Ref.8"Stress-induced gene expression requires programmed recovery from translational repression."_x005F_x005F_x000D_Novoa I., Zhang Y., Zeng H., Jungreis R., Harding H.P., Ron D._x005F_x005F_x000D_EMBO J. 22:1180-1187(2003) [PubMed] [Europe PMC] [Abstract]Cited for: INDUCTION, FUNCTION.Ref.9"The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice."_x005F_x005F_x000D_Kojima E., Takeuchi A., Haneda M., Yagi A., Hasegawa T., Yamaki K., Takeda K., Akira S., Shimokata K., Isobe K._x005F_x005F_x000D_FASEB J. 17:1573-1575(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.Ref.10"Gadd34 requirement for normal hemoglobin synthesis."_x005F_x005F_x000D_Patterson A.D., Hollander M.C., Miller G.F., Fornace A.J. Jr._x005F_x005F_x000D_Mol. Cell. Biol. 26:1644-1653(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, DISRUPTION PHENOTYPE.Ref.11"Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway."_x005F_x005F_x000D_Minami K., Tambe Y., Watanabe R., Isono T., Haneda M., Isobe K., Kobayashi T., Hino O., Okabe H., Chano T., Inoue H._x005F_x005F_x000D_J. Virol. 81:11106-11115(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION. ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.057 ng/mL
1028.4EUR
În stoc
Număr Catalog 247-OKCD00311CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
