Description of target: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.6 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.2"Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2."_x005F_x005F_x000D_Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S., Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F., Kastelein R.A._x005F_x005F_x000D_J. Immunol. 167:1440-1446(2001) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.Ref.9"Regulation and function of the IL-1 family cytokine IL-1F9 in human bronchial epithelial cells."_x005F_x005F_x000D_Chustz R.T., Nagarkar D.R., Poposki J.A., Favoreto S. Jr., Avila P.C., Schleimer R.P., Kato A._x005F_x005F_x000D_Am. J. Respir. Cell Mol. Biol. 45:145-153(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.Ref.10"Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity."_x005F_x005F_x000D_Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M., Gabel C.A., Sims J.E._x005F_x005F_x000D_J. Biol. Chem. 286:42594-42602(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, PROCESSING.Ref.11"IL-36gamma/IL-1F9, an innate T-bet target in myeloid cells."_x005F_x005F_x000D_Bachmann M., Scheiermann P., Hardle L., Pfeilschifter J., Muhl H._x005F_x005F_x000D_J. Biol. Chem. 287:41684-41696(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY.Ref.12"The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses."_x005F_x005F_x000D_Gresnigt M.S., Roesler B., Jacobs C.W., Becker K.L., Joosten L.A., van der Meer J.W., Netea M.G., Dinarello C.A., van de Veerdonk F.L._x005F_x005F_x000D_Eur. J. Immunol. 43:416-426(2013) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION.Ref.13"IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin."_x005F_x005F_x000D_Foster A.M., Baliwag J., Chen C.S., Guzman A.M., Stoll S.W., Gudjonsson J.E., Ward N.L., Johnston A._x005F_x005F_x000D_J. Immunol. 192:6053-6061(2014) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 5.9 pg/mL
1090.8EUR
Preț : 1090.8 €
În stoc
Număr Catalog 247-OKCD00209CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
