Description of target: Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity).By similarity
 <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toiUniProtKB:P27548 (CD40L_MOUSE)3 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"Cloning of TRAP, a ligand for CD40 on human T cells."_x005F_x005F_x000D_Graf D., Korthaeuer U., Mages H.W., Senger G., Kroczek R.A._x005F_x005F_x000D_Eur. J. Immunol. 22:3191-3194(1992) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.Ref.9"Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis."_x005F_x005F_x000D_Blotta M.H., Marshall J.D., DeKruyff R.H., Umetsu D.T._x005F_x005F_x000D_J. Immunol. 156:3133-3140(1996) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.12"The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells."_x005F_x005F_x000D_Mikolajczak S.A., Ma B.Y., Yoshida T., Yoshida R., Kelvin D.J., Ochi A._x005F_x005F_x000D_J. Exp. Med. 199:1025-1031(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION. Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.1 Publication
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.11"Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization."_x005F_x005F_x000D_Furman M.I., Krueger L.A., Linden M.D., Barnard M.R., Frelinger A.L. III, Michelson A.D._x005F_x005F_x000D_J. Am. Coll. Cardiol. 43:2319-2325(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 5.8 pg/mL
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Număr Catalog 247-OKCD00148CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
