Tubulysin A (TubA) is an antibiotic and highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) isolated from myxobacteria. Tubulysins are a family of cytotoxic peptides consisting of 9 members (A-I). Tubulysin A has anti-angiogenic, anti-microtubule, anti-mitotic, and anti-proliferative activities. Tubulysin A is also an inducer of apoptosis (apoptosis), arresting cells in the G2/M phase, effectively inhibiting tubulin polymerization, and inducing depolymerization of detached microtubules. Tubulysin A is potent cytostatic against multiple tumor cell lines with IC50 in the pmol range. Tubulysin A acts as an ADC cytotoxin (ADC Cytotoxin) to synthesize ADC[1][2][3].
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Număr Catalog 804-HY-15995CategorieAfaceri și industrie > Știință și laboratorFurnizorMedChemExpressGentaurDimensiune1mgTipsingle