Anti-MMAE Antibody [PSH0-04] HUABIO

Anti-MMAE Antibody [PSH0-04]

Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer.

Preț : 231 €

În stoc

Număr Catalog 992-HA721257

CategorieAfaceri și industrie > Știință și laboratorFurnizorGentaurDimensiune100ulTipsingle

Produse asociate

Bloguri asociate

Niciun articol disponibil

Te ajutăm să găsești cele mai bune produse pentru cercetarea ta și îți răspundem la întrebări prin chat, email sau telefon. Nu ezita să ne contactezi

Contact

Ai întrebări? Contactează-ne telefonic

Belgia (BE): +32 2 265 09 20

Franța (FR): +33 1 88 38 07 37

Regatul Unit (UK): +44 20 33 938 531

Polonia (PL): +48 58 710 33 44

Germania (DE): +49 241 936 88 188

Statele Unite (US): +1 408 780 09 08

[email protected]
Voortstraat 49, 1910 Kampenhout

Anti-MMAE Antibody [PSH0-04]

Produse asociate

Anti-MMAE Antibody [PSH0-03]

Anti-BrdU Antibody [PSH0-18]

Anti-Ki67 Antibody [PSH0-02]

BrdU Recombinant Antibody [PSH0-18] - Mouse IgG1 (Chimeric)

FITC Conjugated Anti-Mouse CD4 Recombinant Antibody [PSH04-99] - Rabbit IgG (Chimeric)

Rabbit anti-Schizosaccharomyces pombe (strain 972/ATCC 24843)(Fission yeast) psh3 Polyclonal Antibody