Anti-Phospho-IRF3(S386) Antibody [... HUABIO

Anti-Phospho-IRF3(S386) Antibody [SU03-28]

Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor. IRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. The complex translocates into the nucleus for the transcriptional activation of interferons alpha and beta, and further interferon-induced genes. IRF3 plays an important role in the innate immune system's response to viral infection.

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Număr Catalog 992-ET1608-22

CategorieAfaceri și industrie > Știință și laboratorFurnizorGentaurDimensiune100ulTipsingle

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