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Bim(Phospho-Ser77) Rabbit Polyclonal Antibody
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF)| as well as by the forkhead transcription factor FKHR-L1| which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
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Disponibil
Număr Catalog 772-BT-AP00801-100ul
CategorieAfaceri și industrie > Știință și laborator
FurnizorGentaurDimensiune100ulTipsingle
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