GAS Reporter (Luc) - HeLa Cell Lin... BPS Bioscience

GAS Reporter (Luc) - HeLa Cell Line (IFNγ/JAK/STAT1 Pathway)

The GAS reporter (Luc)-HeLa cell line is designed to monitor the activity of interferon gamma-induced signal transduction pathways in cultured cells by measuring activated STAT1 homodimers. It contains a firefly luciferase gene driven by three copies of the interferon gamma-activated sites (GAS) located upstream of the minimal TATA promoter. IFNγ first binds to a heterodimeric receptor consisting of two chains, IFNGR1 and IFNGR2, causing its dimerization and the activation of specific Janus family kinases (JAK1 and JAK2). Two STAT1 molecules associate with this ligand-activated receptor complex and are activated by phosphorylation to form active homodimer. The active STAT1 homodimers translocate to the nucleus where they bind interferon gamma-activated sites (GAS) in the promoter of IFNγ inducible genes, including luciferase reporter gene.

Stoc epuizat

Număr Catalog 421-79041

CategorieAfaceri și industrie > Știință și laboratorFurnizorGentaurDimensiune2 vialsTipsingle

Produse asociate

Bloguri asociate

Niciun articol disponibil

Te ajutăm să găsești cele mai bune produse pentru cercetarea ta și îți răspundem la întrebări prin chat, email sau telefon. Nu ezita să ne contactezi

Contact

Ai întrebări? Contactează-ne telefonic

Belgia (BE): +32 2 265 09 20

Franța (FR): +33 1 88 38 07 37

Regatul Unit (UK): +44 20 33 938 531

Polonia (PL): +48 58 710 33 44

Germania (DE): +49 241 936 88 188

Statele Unite (US): +1 408 780 09 08

[email protected]
Voortstraat 49, 1910 Kampenhout

GAS Reporter (Luc) - HeLa Cell Line (IFNγ/JAK/STAT1 Pathway)

Produse asociate

GAS Luciferase Reporter Lentivirus (IFN-γ/JAK/STAT1 Pathway)

JAK pathway ISRE reporter cell line

Human Stat1 Luciferase Reporter Cell Line- Hela

Hippo Pathway TEAD Luciferase Reporter MCF7 cell line

STAT5 Reporter (Luc)- U937 Cell Line (GM-CSF)

GAS(Luc) Report Cell Line-HeLa