Anti-Human TNF-alpha Antibody ReliaTech

Anti-Human TNF-alpha Antibody

Tumor necrosis factor alpha (TNF-α), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. Human TNF-α consists of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD). Within the ECD, human TNF-α shares 97% aa sequence identity with rhesus and 71% - 92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-α. The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness.

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În stoc

Număr Catalog 209-102-P87

CategorieAfaceri și industrie > Știință și laboratorFurnizorGentaurDimensiune100 µgTipsingle

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Anti-Human TNF-alpha Antibody

Produse asociate

Monoclonal Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #1 aff. Pure

Monoclonal Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #2, aff. Pure

Anti-Human TNF-alpha Antibody

Purified anti-human TNF-alpha antibody, biotin

Anti-Human TNF-alpha sdAb

Rabbit anti-Human TNF-alpha(DET)

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Contact

Belgia (BE): +32 2 265 09 20

Franța (FR): +33 1 88 38 07 37

Regatul Unit (UK): +44 20 33 938 531

Polonia (PL): +48 58 710 33 44

Germania (DE): +49 241 936 88 188

Statele Unite (US): +1 408 780 09 08