IKKß is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. The activity of IKKß is stimulated by TNF and IL1 and IKKß forms a heterodimer that interacts with NIK . Overexpression of catalytically inactive IKKß blocks cytokine-induced NF-kappa-B activation. Aspirin and sodium salicylate can specifically inhibit IKKß activity in vitro and in vivo by binding to IKKß to reduce ATP binding .
370EUR
370EUR
În stoc
Număr Catalog 10021-Z500177CategorieAfaceri și industrie > Știință și laboratorFurnizorABMGentaurDimensiune10 µgTipsingle
