IkappaB-alpha is a protein encoded by the NFKBIA gene which is approximately 35,6 kDa. IkappaB-alpha is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, the TNFR1 pathway, 4-1BB pathway and toll-like receptor signalling pathways. This protein falls under the NF-kappa-B inhibitor family. It inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses it becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. IkappaB-alpha is expressed in adherent monocytes. Mutations in the NFKBIA gene may result in ectodermal dysplasia and leukorrhea. STJ93782 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of IkappaB-alpha protein.
236.4EUR
236.4EUR
În stoc
Număr Catalog 665-STJ93782CategorieAfaceri și industrie > Știință și laboratorFurnizorSt John's LaboratoryGentaurDimensiune200 µlTipsingle
