Description of target: Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.4 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.5"The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression."_x005F_x005F_x000D_Mayr M.I., Huemmer S., Bormann J., Gruener T., Adio S., Woehlke G., Mayer T.U._x005F_x005F_x000D_Curr. Biol. 17:488-498(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.7"The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment."_x005F_x005F_x000D_Stumpff J., von Dassow G., Wagenbach M., Asbury C., Wordeman L._x005F_x005F_x000D_Dev. Cell 14:252-262(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.10"Kinesin-8 molecular motors: putting the brakes on chromosome oscillations."_x005F_x005F_x000D_Gardner M.K., Odde D.J., Bloom K._x005F_x005F_x000D_Trends Cell Biol. 18:307-310(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.11"Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E."_x005F_x005F_x000D_Huang Y., Yao Y., Xu H.-Z., Wang Z.-G., Lu L., Dai W._x005F_x005F_x000D_Cell Cycle 8:2643-2649(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH CENPE. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.127 ng/mL
997.2EUR
997.2EUR
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Număr Catalog 247-OKCD00977CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
