Catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.|Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A| H2B| H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation| cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|PTM:Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.|PTM:Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.|Belongs to the histone deacetylase family. Type 1 subfamily.|subunit:Part of the core histone deacetylase (HDAC) complex composed of HDAC1| HDAC2| RBBP4 and RBBP7. The core complex associates with MTA2| MBD2| MBD3| MTA1L1| CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex| or with SIN3| SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1| HDAC2| HMG20B/BRAF35| AOF2/LSD1| RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2| ZNF217| ZMYM3| GSE1 and GTF2I. Associates with the 9-1-1 complex; interacts with HUS1. Found in a complex with DNMT3A and HDAC7. Interacts with BCOR| BRMS1L| DAXX| DNMT1| EP300| HCFC1| NFE4| PCAF| PHB2| MIER1| KDM4A| MINT| NRIP1| PRDM6| RERE| SETDB1| SUV39H1| TGIF| TGIF2| UHRF1| UHRF2 and ZNF541. Interacts with the non-histone region of H2AFY. Interacts with HDAC9. Component of a mSin3A corepressor complex that contains SIN3A| SAP130| SUDS3/SAP45| ARID4B/SAP180| HDAC1 and HDAC2. Interacts with BANP| CBFA2T3 and KDM5B. Interacts with SAP30L. Interacts with E4F1. Interacts with KFL1 (By similarity). Interacts with SV40 large T antigen.|tissue specificity:Ubiquitous| with higher levels in heart| pancreas and testis| and lower levels in kidney and brain.|
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Număr Catalog 772-BT-AP10351-20ulCategorieAfaceri și industrie > Știință și laboratorFurnizorJiaxing Korain Biotech Ltd (BT Labs)GentaurDimensiune20ulTipsingle
