This gene| a member of the cadherin superfamily| encodes one of the receptor tyrosine kinases| which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development| and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia| type IIA| multiple endocrine neoplasia| type IIB| Hirschsprung disease| and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
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Număr Catalog 772-BT-AP07807-50ulCategorieAfaceri și industrie > Știință și laboratorFurnizorJiaxing Korain Biotech Ltd (BT Labs)GentaurDimensiune50ulTipsingle
