KIT DE TEST MERISCREEN COVID-19 ANTIGEN

Principiu

Testul de detectare a antigenului COVID-19 este un test de imunotest pentru detectarea rapidă și calitativă a infecției cu SARS-CoV-2 de la probe tamponate. Anticorpii monoclonali anti-SARS-CoV-2 sunt acoperiți pe regiunea liniei de testare. Antigenii SARS-CoV-2, dacă sunt prezenți în eșantioane, vor interacționa cu anticorpii monoclonali antiSARS-CoV-2 conjugați cu conjugatul de aur care fac complexul antigen-anticorpi conjugat. Acest complex migrează pe membrană prin acțiune capilară, unde va fi captat de anticorpul monoclonal anti-SARS-CoV-2 acoperit pe linia de testare. O linie de test colorată ar fi vizibilă în fereastra de rezultat dacă antigenii SARS-CoV-2 sunt prezenți în specimen. Intensitatea liniei de testare colorate va varia în funcție de cantitatea de antigen SARS-CoV-2 prezent în specimen.

Îndrumări pentru utilizarea COVID-19 Ag Respi-Strip (CorisBioConcept)

ICMR a validat recent 13 truse de testare antigen COVID-19. Dintre acestea, 3 kituri au fost aprobate pentru utilizare până
acum:
1. STANDARD Q COVID-19 Ag de SD Biosensor
2. COVID-19 Antigen Lateral Test Device of Lab Care Diagnostics Ltd.
3. * COVID-19 Ag Respi-Strip ( CorisBioConcept)
* COVID-19 Ag Respi-Strip (Coris BioConcept) implică o metodologie diferită de testare în comparație cu
celelalte două truse de testare a antigenului aprobate de ICMR până acum. Acest test nu poate fi efectuat la pat și
necesită o configurare BSL-2 pentru a rula testul.

Scurtă metodologie de utilizare a COVID-19 Ag Respi-Strip (CorisBioConcept):

1. Tamponul nazofaringian și / sau orofaringian va fi colectat de la pacientul suspect COVID-19 în
mediu de transport viral (VTM).
2. Tamponul colectat în VTM va fi adus la laborator în condiții corespunzătoare ale lanțului de frig.
3. Odată ce proba este adusă la laborator, va trebui manipulată într-un dulap de nivel BSL-2 pentru
alicotare, punerea în tampon de liză și încărcarea benzii de testare.
 Etapele 1 și 2 vor fi efectuate conform practicii standard urmate pentru colectarea și transportul
probelor pentru testul COVID-19 RT-PCR.
 Pasul 3 va trebui efectuat conform instrucțiunilor producătorilor furnizate împreună cu kitul de testare.

Biocredit Covid-19 Ag Detection Kit
G61RHA20	RapiGEN	20 test cards (pkg)	EUR 95

COVID-19 IgG/IgM Rapid Test Kit
UNCOV-20	UnScience	20T/kit	EUR 155

Description: COVID-19 IgG/IgM Rapid Test (Serum/Plasma/Whole Blood) is a qualitative membrane-based immunoassay for the detection of COVID-19 antibodies in serum, plasma, or whole blood. This test consists of two test lines, an IgG line and an IgM line, which is pre-coated with two mouse anti-human monoclonal antibodies separately. During testing, the sample reacts with COVID-19 antigen-coated on conjugated pad. As the complex continues to travel up the strip, the anti-COVID-19 IgM antibodies are bound on the IgM line, and the anti-COVID-19 IgG antibodies are bound on the IgG line. The control(C)line appears when sample has flowed through the strip. The presence of anti-COVID-19 IgM and/or IgG will be indicated by a visible test line in the IgM and IgG region. To serve as a procedural control, the control line should always appear if the test procedure is performed properly and the reagents are working as intended.

TESTO (Testosterone) ELISA test
19	Biobase	96T/Box	Ask for price

Description: ELISA based test for quantitative detection of O (osterone)

Panbio™ COVID-19 IgG/IgM Rapid Test
ICO-T402	Abbott	25 Tests/Kit	EUR 220

Panbio™ COVID-19 Ag Rapid Test Device
41FK10	Abbott	25 Tests/Kit	EUR 96

Panbio™ COVID-19 Ag Rapid Test Device (Nasal)
41FK11	Abbott	25 Tests/Kit	EUR 95

Description: The Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 is a β -coronavirus, which is an enveloped non-segmented positive-sense RNA virus 2. It is spread by human-to-human transmission via droplets or direct contact, and infection has been estimated to have a mean incubation period of 6.4 days and a basic reproduction number of 2.24-3.58. Among patients with pneumonia caused by SARS-CoV-2, fever was the most common symptom, followed by cough3. The main IVD assays used for COVID-19 employ real-time reverse transcriptase-polymerase chain reaction (RT-PCR) that takes a few hours 4. The availability of a cost-effective, rapid point- of-care diagnostic test is critical to enable healthcare professionals to aid in the diagnosis of patients and prevent further spread of the virus5. Antigen tests will play a critical role in the fight against COVID-19

SARS-CoV-2 (COVID-19) S1 RBD Detection Set
SD9400	ProSci	1 Set	EUR 474.5

Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).

PCRAgH5 AIV Detection Test Kit
PD55-02	Bionote	1 kit	EUR 902.47
Description: Please check the datasheet of PCRAgH5 AIV Detection Test Kit before using the test.

GENLISA™ SARS-CoV-2 (Covid-19) Surrogate Virus Neutralization Test (sVNT) ELISA
KBVH400	Krishgen	12 × 8 wells	EUR 3185

COVID-19 IgG & IgM antibody
GEN-50001-50tests	Ring Bio	50 tests	EUR 324
Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus.

NATtrol Zika Virus Stock (Qualitative) (1 mL)
TEST	Zeptometrix	1 mL	EUR 1106.64

Description: Please contact Gentaur in order to receive the datasheet of the product.

CA153 (Cancer antigen) ELISA test
12	Biobase	96T/Box	Ask for price

Description: ELISA based test for quantitative detection of CA153 (Cancer antigen)

CA199 (Cancer antigen) ELISA test
13	Biobase	96T/Box	Ask for price

Description: ELISA based test for quantitative detection of CA199 (Cancer antigen)

CEA (Cancer antigen) ELISA test
9	Biobase	96T/Box	Ask for price

Description: ELISA based test for quantitative detection of CEA (Cancer antigen)

CA125 (Cancer antigen) ELISA test
11	Biobase	96T/Box	Ask for price

Description: ELISA based test for quantitative detection of CA125 (Cancer antigen)

SARS-CoV-2 (COVID-19) Spike Antibody
3525-002mg	ProSci	0.02 mg	EUR 171.82

Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).

SARS-CoV-2 (COVID-19) Spike Antibody
3525-01mg	ProSci	0.1 mg	EUR 436.42

Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).

SARS-CoV-2 (COVID-19) Envelope Antibody
3531-002mg	ProSci	0.02 mg	EUR 171.82

Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Envelope protein is a small polypeptide that contains at least one alpha-helical transmembrane domain. It involves in several aspects of the virus's life cycle, such as assembly, budding, envelope formation, and pathogenesis. E protein has membrane permeabilizing activity, which provides a possible rationale to inhibit in vitro ion channel activity of some synthetic coronavirus E proteins, and also viral replication (3).

SARS-CoV-2 (COVID-19) Envelope Antibody
3531-01mg	ProSci	0.1 mg	EUR 436.42

Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Envelope protein is a small polypeptide that contains at least one alpha-helical transmembrane domain. It involves in several aspects of the virus's life cycle, such as assembly, budding, envelope formation, and pathogenesis. E protein has membrane permeabilizing activity, which provides a possible rationale to inhibit in vitro ion channel activity of some synthetic coronavirus E proteins, and also viral replication (3).