Calnexin is a protein encoded by the CANX gene which is approximately 67,5 kDa. Calnexin is localised to the endoplasmic reticulum membrane. It is involved in class I MHC mediated antigen processing and presentation, assembly of viral components at the budding site and the calnexin/calreticulin cycle. It is a calcium-binding, endoplasmic reticulum-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It also plays a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Calnexin is expressed in the nervous system, liver, skin, blood and lung. Mutations in the CANX gene may result in Frey syndrome and orbital melanoma. STJ91978 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Calnexin protein.
236.4EUR
În stoc
Număr Catalog 665-STJ91978CategorieAfaceri și industrie > Știință și laboratorFurnizorSt John's LaboratoryGentaurDimensiune200 µlTipsingle
